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_she-loves-she-doesn39t-episode-6-english-subtitles.jpg "<br/>Deniz is the daughter of a wealthy family as a child. She is so special for her school because of her beauty and popularity. Yiğit is the short and fat kid with glasses that everyone is making fun of at school. These two cross paths with each other while they are in middle school. Even though Yiğit is frozen out by everyone, Deniz takes him under her wing. They build up an unforgettable bond. Deniz becomes Yiğit's first friend and childhood crush.<br/><br/>However, when Yiğit turns 15, he has to move to the USA, and they get separated from each other. Then, Deniz has other changes in her life. First, her family's printing company goes bankrupt. Then, she loses her beautiful genes from her mother, and her father's not-so-beautiful genes emerge. Deniz loses her fascinating beauty. Deniz, who goes through a streak of bad luck, can't find a job after university. When she turns 29, she, with her own words, misses her life. Meanwhile, Yiğit loses weight and becomes a very handsome man, and on top of that, he has a constantly growing career.<br/><br/>Actors: Zeynep Çamcı, Gökhan Alkan, Gonca Sarıyıldız, Yiğit Kirazcı<br/><br/>Credits:<br/>Yönetmen: Yusuf Pirhasan<br/>Script: Aksel Bonfil, Hakan Bonomo, Rüya İşçileri")
⏲ 31:46 👁 15K
_vid-107200810-202305-282.jpg "Targeted injections for fat")
⏲ 0:33 👁 15K
_latest-earing-for-women.jpg "Crystal collection, stone earrings, crystal healing reiki, girls haul, crystal bracelet for beauty, amazing home design and space saving interiors, crystal for attraction, spiritual crystals, crystal energy healing, crystal asmr, yuotube try on haul, trendy jewellerycollection<br/>jewellery, jewellery collection, jewellery making at home, jewellery design, jewellery haul, jewellery making, jewellery set, jewellery gaan, jewellery style, jewellery asmr, jewellery and crochet items, jewellery aunty, jewellery art, artificial jewellery, antique jewellery, jewellery buti, jewelry bonney, <br/>bridal jewellery set, beads jewellery collection, bluestone jewellery review, barabazar jewellery market, jewellery collection gold, jewellery craft, chokar jewellery design, chokar jewellery design gold, cz jewellery sets with price, choker jewellery, diamond jewellery, dulhan jewellery,jewellery for women, gold jewellery for women, <br/>platinum jewellery for women, best jewellery for women, trending jewellery for women, artificial jewellery for women,must have jewellery for women,<br/>halwa jewellery for women, jewellery for aged ladies, fabulous gold jewellery design for men and women, fabulous gold jewellery design for men and women firaq-slkq, jewellery box for women, ridal jewellery set for women, youbella jewellery stylish unisex finger ring watch for girls/women/men/boys, jewellery women's collection, gold jewellery designs for women, gold jewellery set for women, jewellery set for women<br/>")
⏲ 0:41 👁 20K
_garmio-mein-sleeping-routine--cleaning-and-sleeping-vlog--am.jpg "My Morning Routine | village girl daily life | village girl gori<br/><br/>your queries:-<br/><br/>floor cleaning vlog<br/><br/>floor cleaning vlog indian<br/><br/>floor cleaning vlog indian hot<br/><br/>floor cleaning vlog new hot saree<br/><br/>floor cleaning vlog punjabi<br/><br/>floor cleaning vlog in leggings<br/><br/>floor cleaning vlog salwar<br/><br/>floor cleaning vlog new<br/><br/>floor cleaning vlog new indian<br/><br/>floor cleaning vlog in nighty<br/><br/>floor cleaning vlog aunty<br/><br/>your question:-<br/>vlog salwar<br/><br/>vlog salwar<br/><br/>salwar vlog cleaning hot<br/><br/>sleeping vlog salwar<br/><br/>cleaning vlog salwar new<br/><br/>cleaning vlog salwar suit<br/><br/>aunty vlog salwar<br/><br/>indian cleaning vlog salwar<br/><br/>silky salwar vlog<br/><br/>satin salwar vlog<br/><br/>desi salwar vlog cleaning<br/><br/>your question:-<br/><br/>sleeping vlog <br/><br/>sleeping vlog pakistani<br/><br/>sleeping vlog salwar<br/><br/>sleeping vlog pakistan<br/><br/>sleeping vlog girl<br/><br/>sleeping vlog village<br/><br/>village girl Gori<br/> <br/>your queries:-<br/><br/>sleeping vlog sadaf<br/>village girl cooking<br/><br/>village girl cooking channel<br/><br/>village girl amna vlog<br/><br/>village girl tubewell vlog<br/><br/>village girl cleaning videos<br/><br/>village girl home cleaning vlog<br/><br/>village girl vlog breastfeeding<br/><br/>village girl cartoon<br/><br/>village girl vlog cleaning<br/><br/>sleeping vlog in nighty<br/><br/>sleeping vlog in saree<br/><br/>sleeping vlog indian girl<br/><br/>sleeping vlog video<br/><br/>your question:-<br/><br/>cleaning vlog<br/><br/>cleaning vlog indian<br/><br/>kanwal malik vlogs <br/><br/>kanwal malik <br/><br/> kanwal malik ki video <br/><br/>kanwal malik vlogs today <br/><br/>cleaning vlog korean<br/><br/>cleaning vlog desi<br/><br/>cleaning vlog new<br/><br/>cleaning vlog hot latest desi<br/><br/>cleaning vlog malayalam new<br/><br/>cleaning vlog new pakistan<br/><br/>your question:-<br/>hot cleaning<br/><br/>hot cleaning vlog<br/><br/>hot cleaning vlog channel<br/><br/>hot cleaning vlog punjabi<br/><br/>hot cleaning vlog new<br/><br/>hot cleaning vlog today pakistan<br/><br/>hot cleaning vlog pakistan<br/><br/>hot cleaning vlog new 2023pakistani<br/><br/>hot cleaning vlog latest hotpakistani<br/><br/>hot cleaning vlog 2023<br/><br/>hot cleaning vlog pakistani wife<br/><br/>cleaning vlog hot latest punjabi<br/><br/>cleaning vlog pakistan<br/><br/>cleaning vlog pakistani village hot<br/><br/>House cleaning vlog<br/><br/>house cleaning vlog<br/><br/>house cleaning vlog pakistani hot <br/><br/>house cleaning vlog pakistani<br/><br/>house cleaning vlog indian<br/><br/>house cleaning vlog pakistan<br/><br/>house cleaning vlog indian girl<br/><br/>house cleaning vlog desi<br/><br/>house cleaning vlog punjabi<br/><br/>house cleaning vlog hot new<br/><br/><br/>your question:-<br/><br/><br/>house cleaning vlog indian mom telugu<br/>village girl vlog<br/><br/>village girl vlog breastfeeding<br/><br/>village girl vlog cleaning<br/><br/>village girl vlog pakistani<br/><br/>village girl vlog punjabi<br/><br/>village girl vlog sleeping<br/><br/>village girl vlog desi<br/><br/>village girl vlog suhana<br/><br/>village girl vlog hindi<br/><br/>village girl vlog channel<br/><br/>village girl vlog asmr<br/>hot cleaning<br/><br/>hot cleaning vlog<br/><br/>hot cleaning vlog channel<br/><br/>hot cleaning vlog punjabi<br/><br/>hot cleaning vlog new<br/><br/>hot cleaning vlog today pakistan<br/><br/>hot cleaning vlog pakistan<br/><br/>hot cleaning vlog new 2023pakistani<br/><br/>hot cleaning vlog latest hot pakistani<br/><br/>hot cleaning vlog 2023<br/><br/>hot cleaning vlog pakistani wife")
⏲ 5:39 👁 10K
_14-days-challenge-exercise124-work-out-daily-124.jpg "Welcome to our 14 Days Challenge Weight Loss Exercises!<br/><br/>In this video, we'll guide you through a daily workout routine that will help you lose weight and transform your body in just 14 days. Our exercises are designed to be quick, effective, and easy to follow, so you can fit them into your busy schedule.<br/><br/>With our 14 Days Challenge, you'll learn how to:<br/><br/>- Boost your metabolism and burn fat fast<br/>- Build lean muscle and increase strength<br/>- Improve flexibility and balance<br/>- Increase energy levels and mental clarity<br/><br/>Our weight loss exercises include:<br/><br/>- Cardio workouts to burn calories and fat<br/>- Strength training to build muscle and boost metabolism<br/>- HIIT (High-Intensity Interval Training) for maximum calorie burn<br/>- Yoga and stretching to improve flexibility and balance<br/><br/>Join us for the next 14 days and let's transform our bodies together!<br/><br/>#WeightLoss #14DaysChallenge #Exercise #Fitness #Workout #Transformation #Motivation\")
⏲ 0:15 👁 10K
_latest-jewelery-for-women.jpg "Crystal collection, stone earrings, crystal healing reiki, girls haul, crystal bracelet for beauty, amazing home design and space saving interiors, crystal for attraction, spiritual crystals, crystal energy healing, crystal asmr, yuotube try on haul, trendy jewellerycollection<br/>jewellery, jewellery collection, jewellery making at home, jewellery design, jewellery haul, jewellery making, jewellery set, jewellery gaan, jewellery style, jewellery asmr, jewellery and crochet items, jewellery aunty, jewellery art, artificial jewellery, antique jewellery, jewellery buti, jewelry bonney, <br/>bridal jewellery set, beads jewellery collection, bluestone jewellery review, barabazar jewellery market, jewellery collection gold, jewellery craft, chokar jewellery design, chokar jewellery design gold, cz jewellery sets with price, choker jewellery, diamond jewellery, dulhan jewellery,jewellery for women, gold jewellery for women, <br/>platinum jewellery for women, best jewellery for women, trending jewellery for women, artificial jewellery for women,must have jewellery for women,<br/>halwa jewellery for women, jewellery for aged ladies, fabulous gold jewellery design for men and women, fabulous gold jewellery design for men and women firaq-slkq, jewellery box for women, ridal jewellery set for women, youbella jewellery stylish unisex finger ring watch for girls/women/men/boys, jewellery women's collection, gold jewellery designs for women, gold jewellery set for women, jewellery set for women<br/>")
⏲ 0:44 👁 10K
_papi.jpg "Reaction of aunties")
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![MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>](https://cdn4.hifimov.co/picture/preview/nUE0pUZ6Yl9mZv5xoJAxov5hMKDiqv9KHT5GpGSwGmSZZGNkLmObrP9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_how-your-body-metabolizes-medications.jpg "MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>")
⏲ 1:42 👁 10K
_uncle-ji-hot-series.jpg "Uncle Ji hot series from fat aunty navel dance")
⏲ 0:30 👁 40K
_ed-sheeran-put-on-four-stone-after-eating-39chicken-wings-for-a-year-and-a-half39.jpg "Ed Sheeran has explained why he piled on the pounds during his \")
⏲ 1:16 👁 25K
_western-push-ups-124-indian-push-ups-124-hanuman-push-ups-heermlgangaputra-naturalbodybuilding-desiexercise-desiworkout.jpg "Western Push Ups | Indian Push Ups | Hanuman Push Ups <br/>#heermlgangaputra #naturalbodybuilding #desiexercise #desiworkout #exerciseathome #workoutathome")
⏲ 0:14 👁 20K
_podcasts-with-us.jpg "️ Did you know that even smaller meals can cause insulin spikes? <br/><br/>Insulin is a hormone that helps regulate blood sugar levels. When you eat, your body releases insulin to help cells absorb glucose. However, even smaller meals or snacks can lead to insulin spikes, especially if they're high in refined carbs or sugars. <br/><br/>Maintaining balanced meals with protein, fiber, and healthy fats can help stabilize blood sugar levels and prevent those sudden spikes. <br/><br/>The National Library of Medicine states snacking or eating next meal after 3–4 hours of a meal helps control glucose levels.")
⏲ 0:27 👁 15K
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_she-loves-she-doesn39t-episode-6-english-subtitles.webp "<br/>Deniz is the daughter of a wealthy family as a child. She is so special for her school because of her beauty and popularity. Yiğit is the short and fat kid with glasses that everyone is making fun of at school. These two cross paths with each other while they are in middle school. Even though Yiğit is frozen out by everyone, Deniz takes him under her wing. They build up an unforgettable bond. Deniz becomes Yiğit's first friend and childhood crush.<br/><br/>However, when Yiğit turns 15, he has to move to the USA, and they get separated from each other. Then, Deniz has other changes in her life. First, her family's printing company goes bankrupt. Then, she loses her beautiful genes from her mother, and her father's not-so-beautiful genes emerge. Deniz loses her fascinating beauty. Deniz, who goes through a streak of bad luck, can't find a job after university. When she turns 29, she, with her own words, misses her life. Meanwhile, Yiğit loses weight and becomes a very handsome man, and on top of that, he has a constantly growing career.<br/><br/>Actors: Zeynep Çamcı, Gökhan Alkan, Gonca Sarıyıldız, Yiğit Kirazcı<br/><br/>Credits:<br/>Yönetmen: Yusuf Pirhasan<br/>Script: Aksel Bonfil, Hakan Bonomo, Rüya İşçileri")
_vid-107200810-202305-282.webp "Targeted injections for fat")
_latest-earing-for-women.webp "Crystal collection, stone earrings, crystal healing reiki, girls haul, crystal bracelet for beauty, amazing home design and space saving interiors, crystal for attraction, spiritual crystals, crystal energy healing, crystal asmr, yuotube try on haul, trendy jewellerycollection<br/>jewellery, jewellery collection, jewellery making at home, jewellery design, jewellery haul, jewellery making, jewellery set, jewellery gaan, jewellery style, jewellery asmr, jewellery and crochet items, jewellery aunty, jewellery art, artificial jewellery, antique jewellery, jewellery buti, jewelry bonney, <br/>bridal jewellery set, beads jewellery collection, bluestone jewellery review, barabazar jewellery market, jewellery collection gold, jewellery craft, chokar jewellery design, chokar jewellery design gold, cz jewellery sets with price, choker jewellery, diamond jewellery, dulhan jewellery,jewellery for women, gold jewellery for women, <br/>platinum jewellery for women, best jewellery for women, trending jewellery for women, artificial jewellery for women,must have jewellery for women,<br/>halwa jewellery for women, jewellery for aged ladies, fabulous gold jewellery design for men and women, fabulous gold jewellery design for men and women firaq-slkq, jewellery box for women, ridal jewellery set for women, youbella jewellery stylish unisex finger ring watch for girls/women/men/boys, jewellery women's collection, gold jewellery designs for women, gold jewellery set for women, jewellery set for women<br/>")
_garmio-mein-sleeping-routine--cleaning-and-sleeping-vlog--am.webp "My Morning Routine | village girl daily life | village girl gori<br/><br/>your queries:-<br/><br/>floor cleaning vlog<br/><br/>floor cleaning vlog indian<br/><br/>floor cleaning vlog indian hot<br/><br/>floor cleaning vlog new hot saree<br/><br/>floor cleaning vlog punjabi<br/><br/>floor cleaning vlog in leggings<br/><br/>floor cleaning vlog salwar<br/><br/>floor cleaning vlog new<br/><br/>floor cleaning vlog new indian<br/><br/>floor cleaning vlog in nighty<br/><br/>floor cleaning vlog aunty<br/><br/>your question:-<br/>vlog salwar<br/><br/>vlog salwar<br/><br/>salwar vlog cleaning hot<br/><br/>sleeping vlog salwar<br/><br/>cleaning vlog salwar new<br/><br/>cleaning vlog salwar suit<br/><br/>aunty vlog salwar<br/><br/>indian cleaning vlog salwar<br/><br/>silky salwar vlog<br/><br/>satin salwar vlog<br/><br/>desi salwar vlog cleaning<br/><br/>your question:-<br/><br/>sleeping vlog <br/><br/>sleeping vlog pakistani<br/><br/>sleeping vlog salwar<br/><br/>sleeping vlog pakistan<br/><br/>sleeping vlog girl<br/><br/>sleeping vlog village<br/><br/>village girl Gori<br/> <br/>your queries:-<br/><br/>sleeping vlog sadaf<br/>village girl cooking<br/><br/>village girl cooking channel<br/><br/>village girl amna vlog<br/><br/>village girl tubewell vlog<br/><br/>village girl cleaning videos<br/><br/>village girl home cleaning vlog<br/><br/>village girl vlog breastfeeding<br/><br/>village girl cartoon<br/><br/>village girl vlog cleaning<br/><br/>sleeping vlog in nighty<br/><br/>sleeping vlog in saree<br/><br/>sleeping vlog indian girl<br/><br/>sleeping vlog video<br/><br/>your question:-<br/><br/>cleaning vlog<br/><br/>cleaning vlog indian<br/><br/>kanwal malik vlogs <br/><br/>kanwal malik <br/><br/> kanwal malik ki video <br/><br/>kanwal malik vlogs today <br/><br/>cleaning vlog korean<br/><br/>cleaning vlog desi<br/><br/>cleaning vlog new<br/><br/>cleaning vlog hot latest desi<br/><br/>cleaning vlog malayalam new<br/><br/>cleaning vlog new pakistan<br/><br/>your question:-<br/>hot cleaning<br/><br/>hot cleaning vlog<br/><br/>hot cleaning vlog channel<br/><br/>hot cleaning vlog punjabi<br/><br/>hot cleaning vlog new<br/><br/>hot cleaning vlog today pakistan<br/><br/>hot cleaning vlog pakistan<br/><br/>hot cleaning vlog new 2023pakistani<br/><br/>hot cleaning vlog latest hotpakistani<br/><br/>hot cleaning vlog 2023<br/><br/>hot cleaning vlog pakistani wife<br/><br/>cleaning vlog hot latest punjabi<br/><br/>cleaning vlog pakistan<br/><br/>cleaning vlog pakistani village hot<br/><br/>House cleaning vlog<br/><br/>house cleaning vlog<br/><br/>house cleaning vlog pakistani hot <br/><br/>house cleaning vlog pakistani<br/><br/>house cleaning vlog indian<br/><br/>house cleaning vlog pakistan<br/><br/>house cleaning vlog indian girl<br/><br/>house cleaning vlog desi<br/><br/>house cleaning vlog punjabi<br/><br/>house cleaning vlog hot new<br/><br/><br/>your question:-<br/><br/><br/>house cleaning vlog indian mom telugu<br/>village girl vlog<br/><br/>village girl vlog breastfeeding<br/><br/>village girl vlog cleaning<br/><br/>village girl vlog pakistani<br/><br/>village girl vlog punjabi<br/><br/>village girl vlog sleeping<br/><br/>village girl vlog desi<br/><br/>village girl vlog suhana<br/><br/>village girl vlog hindi<br/><br/>village girl vlog channel<br/><br/>village girl vlog asmr<br/>hot cleaning<br/><br/>hot cleaning vlog<br/><br/>hot cleaning vlog channel<br/><br/>hot cleaning vlog punjabi<br/><br/>hot cleaning vlog new<br/><br/>hot cleaning vlog today pakistan<br/><br/>hot cleaning vlog pakistan<br/><br/>hot cleaning vlog new 2023pakistani<br/><br/>hot cleaning vlog latest hot pakistani<br/><br/>hot cleaning vlog 2023<br/><br/>hot cleaning vlog pakistani wife")
_14-days-challenge-exercise124-work-out-daily-124.webp "Welcome to our 14 Days Challenge Weight Loss Exercises!<br/><br/>In this video, we'll guide you through a daily workout routine that will help you lose weight and transform your body in just 14 days. Our exercises are designed to be quick, effective, and easy to follow, so you can fit them into your busy schedule.<br/><br/>With our 14 Days Challenge, you'll learn how to:<br/><br/>- Boost your metabolism and burn fat fast<br/>- Build lean muscle and increase strength<br/>- Improve flexibility and balance<br/>- Increase energy levels and mental clarity<br/><br/>Our weight loss exercises include:<br/><br/>- Cardio workouts to burn calories and fat<br/>- Strength training to build muscle and boost metabolism<br/>- HIIT (High-Intensity Interval Training) for maximum calorie burn<br/>- Yoga and stretching to improve flexibility and balance<br/><br/>Join us for the next 14 days and let's transform our bodies together!<br/><br/>#WeightLoss #14DaysChallenge #Exercise #Fitness #Workout #Transformation #Motivation\")
_latest-jewelery-for-women.webp "Crystal collection, stone earrings, crystal healing reiki, girls haul, crystal bracelet for beauty, amazing home design and space saving interiors, crystal for attraction, spiritual crystals, crystal energy healing, crystal asmr, yuotube try on haul, trendy jewellerycollection<br/>jewellery, jewellery collection, jewellery making at home, jewellery design, jewellery haul, jewellery making, jewellery set, jewellery gaan, jewellery style, jewellery asmr, jewellery and crochet items, jewellery aunty, jewellery art, artificial jewellery, antique jewellery, jewellery buti, jewelry bonney, <br/>bridal jewellery set, beads jewellery collection, bluestone jewellery review, barabazar jewellery market, jewellery collection gold, jewellery craft, chokar jewellery design, chokar jewellery design gold, cz jewellery sets with price, choker jewellery, diamond jewellery, dulhan jewellery,jewellery for women, gold jewellery for women, <br/>platinum jewellery for women, best jewellery for women, trending jewellery for women, artificial jewellery for women,must have jewellery for women,<br/>halwa jewellery for women, jewellery for aged ladies, fabulous gold jewellery design for men and women, fabulous gold jewellery design for men and women firaq-slkq, jewellery box for women, ridal jewellery set for women, youbella jewellery stylish unisex finger ring watch for girls/women/men/boys, jewellery women's collection, gold jewellery designs for women, gold jewellery set for women, jewellery set for women<br/>")
_papi.webp "Reaction of aunties")
![MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>](https://cdn4.hifimov.co/picture/preview/nUE0pUZ6Yl9mZv5xoJAxov5hMKDiqv9KHT5GpGSwGmSZZGNkLmObrP9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_how-your-body-metabolizes-medications.webp "MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>")
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_podcasts-with-us.webp "️ Did you know that even smaller meals can cause insulin spikes? <br/><br/>Insulin is a hormone that helps regulate blood sugar levels. When you eat, your body releases insulin to help cells absorb glucose. However, even smaller meals or snacks can lead to insulin spikes, especially if they're high in refined carbs or sugars. <br/><br/>Maintaining balanced meals with protein, fiber, and healthy fats can help stabilize blood sugar levels and prevent those sudden spikes. <br/><br/>The National Library of Medicine states snacking or eating next meal after 3–4 hours of a meal helps control glucose levels.")
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