_optimisation-of-nanb-inhibitiors-based-upon-ches-part-1.jpg "Optimisation of NanB Inhibitiors based upon CHES part 1 from nanb Video Screenshot Preview")
GalleryPlay Video:
(Note: The default playback of the video is HD VERSION. If your browser is buffering the video slowly, please play the REGULAR MP4 VERSION or Open The Video below for better experience. Thank you!)
⏲ Duration: 90 sec
✓ Published: 21-Aug-2016
✓ Published: 21-Aug-2016
Description:
This is Part 1 of a summary of the crystal structures presented in Synthesis and Structural Characterisation of Selective Non-Carbohydrate-Based Inhibitors of Bacterial Sialidases - (Brear - 2012 - ChemBioChem ). In this paper CHES was initially identified as a serendipitous binding fragment in the active site of NanB. CHES was fragmented down to the minimum binding unit taurine which was then further optimised.
This is Part 1 of a summary of the crystal structures presented in Synthesis and Structural Characterisation of Selective Non-Carbohydrate-Based Inhibitors of Bacterial Sialidases - (Brear - 2012 - ChemBioChem ). In this paper CHES was initially identified as a serendipitous binding fragment in the active site of NanB. CHES was fragmented down to the minimum binding unit taurine which was then further optimised.
Share with your friends:
Whatsapp | Viber | Telegram | Line | SMS
Email | Twitter | Reddit | Tumblr | Pinterest
Related Videos
_the-essentials-of-telenursing-practice-2023.webp "NANB AIINB")
_optimisation-of-nanb-inhibitiors-based-upon-ches-part-2.webp "This is Part 2 of a summary of the crystal structures presented in Synthesis and Structural Characterisation of Selective Non-Carbohydrate-Based Inhibitors of Bacterial Sialidases - (Brear - 2012 - ChemBioChem). The active site of NanB is covered by a flexible loop. This loop is normally held in position by a well defined water. In the structure with taurine the water can be seen and the loop is rigid, as can be seen from the B-factor putty representation (increased size and red means larger B-f")
_les-mdias-sociaux-lutilisation-dappareils-mobiles-et-de-ti-au-travail.webp "NANB AIINB")
⏲ 16 minutes 11 seconds 👁 54
_social-media-mobile-devices-and-information-technologies-its-use-in-the-workplace.webp "NANB AIINB")
⏲ 15 minutes 34 seconds 👁 161
_la-gestion-des-mdicaments.webp "NANB AIINB")
_nanb-medicationmanagement-2020.webp "NANB AIINB")
_optimisation-of-nanb-inhibitiors-based-upon-ches-part-3.webp "This is Part 3 of a summary of the crystal structures presented in Synthesis and Structural Characterisation of Selective Non-Carbohydrate-Based Inhibitors of Bacterial Sialidases - (Brear - 2012 - ChemBioChem ). The structures detailing the optimization of the 4'-position of the phenyl ring. Cl causes the Met to move slightly enlarging the hydrophobic pocket, but also forms a halogen bond interaction with the Met leading to and increase in affinity. Whereas in order to accommodate MeO in the 4'")
_numb-official-music-video-4k-upgrade-linkin-park.webp "Linkin Park")
_the-essentials-of-telenursing-practice-2023.jpg)
_optimisation-of-nanb-inhibitiors-based-upon-ches-part-2.jpg)
_les-mdias-sociaux-lutilisation-dappareils-mobiles-et-de-ti-au-travail.jpg)
_social-media-mobile-devices-and-information-technologies-its-use-in-the-workplace.jpg)
_la-gestion-des-mdicaments.jpg)
_nanb-medicationmanagement-2020.jpg)
_optimisation-of-nanb-inhibitiors-based-upon-ches-part-3.jpg)
_numb-official-music-video-4k-upgrade-linkin-park.jpg)
![[+]](/images/menu.gif){kind=small}